90 YEARS OF PROGESTERONE: Progesterone and progesterone receptors in breast cancer: past, present, future
نویسندگان
چکیده
منابع مشابه
Progesterone and progesterone receptors in experimental breast cancer.
in ER-positive tumors would indicate that the tumor is capa ble of synthesizing at least 1 end product under estrogen regulation and may therefore be endocrine responsive (8). Although the hypothesis assumes that PGR levels in breast tumors, like those in the uterus, are under estrogen control, this priming effect has never been demonstrated. In this paper we show that PGR in the DMBA-induced m...
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Background & objective: Breast cancer is the leading cause of cancer related death in females. Sphingosine kinase 1 (SPHK1) and its product sphingosine-1-phosphate (S1P) are the essential key regulator molecules in breast cancer through their ability to promote cell proliferation, angiogenesis, cell proliferation, and lymphagiogenesis. SPHK1 i...
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Nuclear receptors play an important role in transcriptional regulation of diverse cellular processes and is also relevant in diseases such as cancer. In breast cancer, the nuclear receptors - estrogen receptor (ER) and progesterone receptor (PR) are classical markers of the disease and are used to classify breast cancer subtypes. Using a recently developed affinity purification MS technique (RI...
متن کاملProgesterone acts via progesterone receptors A and B to regulate breast cancer resistance protein expression.
The breast cancer resistance protein (BCRP; ABCG2) is an ATP-dependent efflux multidrug transporter that belongs to the G family of half-transporters that consist of six transmembrane-spanning domains and must homodimerize to form the active membrane transporter. It is expressed in the apical plasma membrane domain of the small intestine, endothelium, and liver, where it has been shown to play ...
متن کاملProgesterone metabolites in breast cancer.
In the 70 years since progesterone (P) was identified in corpus luteum extracts, its metabolism has been examined extensively in many tissues and cell lines from numerous species. In addition to the reproductive tissues and adrenals, every other tissue that has been investigated appears to have one or more P-metabolizing enzyme, each of which is specific for a particular site on the P molecule....
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ژورنال
عنوان ژورنال: Journal of Molecular Endocrinology
سال: 2020
ISSN: 0952-5041,1479-6813
DOI: 10.1530/jme-20-0104